LSS-3000 Ultra-Fast Solution Switching

Burleigh's Piezoelectric Ultrafast Solution Switching Systems can change the chemical environment of a whole cell or excised patch with sub-millisecond time resolution. These systems are complete, practical and easy-to-implement approaches for rapidly moving a theta tube and its exiting solution stream. Now you can uncover the actual kinetics of ion channels, reconstruct the naturally occurring conditions at the synapse of a neuron and eliminate the problem of desensitization resulting from longer time exposures to a drug in pharmacological studies.

• One way solution switching in less than 100µsec
• Two way solution pulses in less than 1 msec
• Smooth stable and accurate linear motion using solid-state PZT actuators integrated with monolithic flexure stages
• Simple electronic integration with Axon PClamp or other patch clamp hardware & software
• Universal angle theta tube mounting system
• Complete microscope mounting solutions
• Up to 300µm PZT travel for easy alignment
• Integrated manual stages & adjustments for easy coarse alignment
• Up to 20 times faster than stepper motor systems
• Overcomes problems of desensitization with slower systems

LSS-3000 Series Ultrafast Solution Switching System
This consists of components with the following modules:

Components

PZS-100HS & PS-200 Microstages
These are PZT actuated flexure stages that generate straight vibration-free motion in a small robust package. The micropipette is mounted on the top surface which moves by amplified PZT motion relative to the fixed bottom of the stage. This design is compact and rugged with low pitch and yaw errors. The minimum time to move the full range of motion is less than 1 millisecond.

LS-10 Mounting System and CP-300 Manual Stage Assembly
These combine to provide a very stable yet flexible universal mounting system for integration with virtually any microscope.

• All PZS Series MicroStages can be mounted to the LS-10 mounting system

• Accommodates pipettes and theta tubing up to 3mm diameter

• The LS-10 can be used separately with other manual stages that can hold its 0.75 inch rod

• The CP-300 provides six degrees of freedom. The X,Y, and Z axes have manual adjusters with 25mm travel and 10µm resolution.

• The CP-300 can be mounted to all Burleigh PCS-500 Series Microscope Mounts

The PZ-150M Amplifier/Driver
This is an analog high voltage power supply with sufficient power & frequency response to drive the PZS MicroStages at maximum speed. The power supply accepts 0 to ±10V input. The actual output voltage is shown on a digital front panel display. The PZ-150M does not have the programmable intelligence of the PZ-100. Thus the step size, ramp shape and speed are set by the input drive signal. Gain & DC offset are adjusted by front panel knobs.

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